Konkona was born on 3 December 1979 in New Delhi, India. She is an acclaimed National Award winning Indian actress. She is the daughter of director Aparna Sen.

Konkona's birth father, Mukul Sharma, is a science writer and journalist.

Konkona's maternal grandfather, Chidananda Dasgupta, who is now 88 years old, is a film critic, scholar, professor, writer and one of the co-founders of the Calcutta Film Society with Satyajit Ray and Harisadhan Dasgupta. Her grandmother Supriya Dasgupta is a cousin of legendary modern Bengali poet Jibanananda Das.

Konkona's graduate degree was in English, from St. Stephen's College, Delhi in 2001. She was a student of the Modern High School for Girls, Calcutta, as well as the Calcutta International School.

She made her debut as a child artist in the film Indira. She became a known face when she starred in the film Mr. and Mrs. Iyer, directed by her mother. The film was a multiplex success and was a favourite with the critics. Konkona's performance got her the National Film Award for Best Actress. This was followed by a critically acclaimed hit, Page 3 (2005). Her role drew a lot of praise and she became a more familiar face to the movie going public.

She followed it up with even more acclaimed performances in 15 Park Avenue (2005) and Omkara (2006). Her movie Deadline: Sirf 24 Ghante (2006) got average reviews. Her filmTraffic Signal (2007) is also critically acclaimed and she has received good reviews for her performance. Her latest release Life in a ... Metro is also critically acclaimed and got good reviews. Her performance in this movie as a confused girl who is looking for Mr. Right is commendable. Her comming up release is Laaga Chunari Mein Daag directed by Pradeep Sarkar, released form Yash Raj Films with commercial actors like Rani Mukherjee and Abhishek Bachchan.

Sharma recently received her first Filmfare Award in the Best Supporting Actress category for her performance in Omkara.

Her movie Amu (2005) has won critical acclaim and has been shown in various film festivals in Europe.